Overcoming Resistance by Targeting Adaptive Stress

We believe that adaptive stress is a critical tumor survival mechanism that may limit our ability to eliminate highly resistant cancer cells that can lead to disease progression and death. Despite the clinical improvements that have been made with the use of targeted therapies, cancer cells leverage adaptive stress pathways to adapt, survive, and become resistant to treatment.

We are leading the way in understanding how to target the adaptive stress response for cancer therapy. We believe blocking these key mechanisms that resistant cancer cells use to survive has the potential to provide efficacy and durability across the cancer landscape.