Working to Exploit Stress Driven Vulnerabilities in Cancer Cells

Despite clinical improvements made with the use of approved precision therapies and therapeutic candidates, cancer cells leverage adaptive stress-mitigating pathways and immunosuppression to adapt, survive, and become resistant to treatment.  However, stress also causes cells to be more vulnerable to alternative therapeutic approaches.  We believe that we can work to exploit these vulnerabilities through the following approaches:

• Inhibition: Strive to prevent cancer cell survival and adaptation by inhibiting stress-mitigation pathways
• Activation: Work to increase stress signaling by overwhelming stress-mitigation pathways and inducing apoptosis (cell death)
• Immune Modulation: Aim to target tumor-immune interactions to exploit stress-induced vulnerabilities in the tumor microenvironment