Targeting Adaptive Stress and Innate Immunity

We have developed a deep and differentiated pipeline of therapy candidates that address dynamic drivers of treatment resistance, cancer relapse and metastasis.
By combining our translational expertise with our proprietary QuAD3 platform, we believe we can enhance our clinical development efforts by identifying patients most likely to respond to our therapeutic candidates, while simultaneously enhancing our discovery efforts to expand our pipeline of innovative therapeutic candidates in cancer and other indications.

Our Pipeline

Phase 1
Phase 2
Phase 3
Adaptive Stress Modulators
Advanced RCC, Gastric Cancer & Other Advanced Solid Tumors
HC-5404 monoTx

HC-5404, our first adaptive stress product candidate, is a differentiated highly selective, orally bioavailable inhibitor of a key stress response protein kinase, PERK. We are developing HC-5404 for stress driven tumors, including von Hippel-Lindau, or VHL, mutated RCC, gastric cancer and other solid tumors.

Advanced HNSCC, CRC, Bladder Cancer & Other Advanced Solid Tumors
HC-7366 monoTx

HC-7366, our second adaptive stress product candidate, is a differentiated selective, orally bioavailable modulator of another key stress response protein kinase, GCN2.  We are developing HC-7366 for the treatment of advanced solid tumors and are exploring the potential of HC-7366 in hematological malignancies.

Innate & Adaptive Immune Modulator
mBC Post HR Tx Failure
Odetiglucan + Pembrolizumab
Pancreatic Cancer
Liver Metastasis

Odetiglucan (Imprime PGG) is our systemically administered innate and adaptive immune modulator therapeutic candidate.   We are conducting a Phase 2 clinical trial of odetiglucan in combination with pembrolizumab in adults with metastatic, hormone-refractory breast cancer patients and plan to submit INDs for Phase 1b clinical trials in combination with a CD40 agonistic antibody in pancreatic cancer and as monotherapy in liver metastasis.

Targeting critical adaptive stress response pathways

Modulating the immune system’s defense mechanisms