HC-7366 is a differentiated, orally bioavailable investigational small molecule activator of GCN2. GCN2 (General Controlled Nonderepressible 2), one of the kinases of the Integrated Stress Response (ISR) family responds to amino acid deprivation and is a key metabolic stress sensor in cells. Preclinically, hyperactivation of the ISR via GCN2 has been demonstrated to result in anti-tumor activity and amelioration of an immunosuppressive tumor microenvironment as a monotherapy and in combination with multiple standard-of-care agents across liquid and solid tumors.