Innate and Adaptive Immunity

About Innate and Adaptive Immunity
About Innate and Adaptive Immunity
Joyce et al. 2009. PMID: 19279573

Overcoming Limitations of Current Immunotherapies

Recent advancements with immunotherapies, including immune checkpoint inhibitors, have achieved limited benefit.  Most patients fail to benefit from checkpoint therapies because of one or more of the following:

  • Insufficient tumor antigens
  • Poor antigen presentation
  • Limited T cell trafficking and infiltration
  • Limited T cell potential due to immunosuppressive tumor microenvironment

We believe that systemically activating the innate and adaptive immune systems with our investigational immune modulator, odetiglucan, has the potential to improve antigen presentation, T cell recruitment, T cell activation, alleviate immunosuppression in the tumor microenvironment and lead to more robust anti-tumor responses in combination with immune checkpoint inhibitors.

Avoiding the Challenges Associated with Other Systemically Administered Innate Immune Modulators

Clinical development of other innate immune modulators, such as cGAS-STING, Toll-Like Receptors, RIG-I, and NOD-like, has been challenging due to multiple factors including, but not limited to, short half-life, toxicities, narrow therapeutic index and the limited ability to get drug to the target site.  As a result, many innate immune modulators must employ intratumoral administration, without the benefit of systemic activation of innate and adaptive immunity and therapeutic benefit at other tumor sites.

We believe odetiglucan’s potential is driven by its low levels of cytokine and chemokine induction, enhancement of innate and adaptive immune cell-mediated tumor killing, and reprogramming of the tumor microenvironment.

Overcoming the Immunosuppressive Tumor Microenvironment

We have observed in preclinical studies that our innate and adaptive immune modulator agonizes Dectin-1, which primes a de novo T Cell immune response, reprograms the immunosuppressive tumor microenvironment and induces trained innate immunity, which collectively, can lead to a more durable anti-tumor immune response.